Potent and persistent antibody responses against the receptor-binding domain of SARS-CoV spike protein in recovered patients.
Identifieur interne : 002480 ( Main/Exploration ); précédent : 002479; suivant : 002481Potent and persistent antibody responses against the receptor-binding domain of SARS-CoV spike protein in recovered patients.
Auteurs : Zhiliang Cao [République populaire de Chine] ; Lifeng Liu ; Lanying Du ; Chao Zhang ; Shibo Jiang ; Taisheng Li ; Yuxian HeSource :
- Virology journal [ 1743-422X ] ; 2010.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (sang), Anticorps neutralisants (sang), Facteurs temps, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (immunologie), Humains, Protéines de l'enveloppe virale (immunologie), Structure tertiaire des protéines, Syndrome respiratoire aigu sévère (immunologie), Test ELISA, Tests de neutralisation, Virus du SRAS (immunologie), Études de suivi.
- MESH :
- immunologie : Glycoprotéines membranaires, Protéines de l'enveloppe virale, Syndrome respiratoire aigu sévère, Virus du SRAS.
- sang : Anticorps antiviraux, Anticorps neutralisants.
- Animaux, Facteurs temps, Glycoprotéine de spicule des coronavirus, Humains, Structure tertiaire des protéines, Test ELISA, Tests de neutralisation, Études de suivi.
English descriptors
- KwdEn :
- Animals, Antibodies, Neutralizing (blood), Antibodies, Viral (blood), Enzyme-Linked Immunosorbent Assay, Follow-Up Studies, Humans, Membrane Glycoproteins (immunology), Neutralization Tests, Protein Structure, Tertiary, SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Spike Glycoprotein, Coronavirus, Time Factors, Viral Envelope Proteins (immunology).
- MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- chemical , immunology : Membrane Glycoproteins, Viral Envelope Proteins.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome.
- Animals, Enzyme-Linked Immunosorbent Assay, Follow-Up Studies, Humans, Neutralization Tests, Protein Structure, Tertiary, Spike Glycoprotein, Coronavirus, Time Factors.
Abstract
The spike (S) protein of SARS-CoV not only mediates receptor-binding but also induces neutralizing antibodies. We previously identified the receptor-binding domain (RBD) of S protein as a major target of neutralizing antibodies in animal models and thus proposed a RBD-based vaccine. However, the antigenicity and immunogenicity of RBD in humans need to be characterized.
DOI: 10.1186/1743-422X-7-299
PubMed: 21047436
Affiliations:
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Le document en format XML
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Cao</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Liu, Lifeng" sort="Liu, Lifeng" uniqKey="Liu L" first="Lifeng" last="Liu">Lifeng Liu</name></author><author><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name></author><author><name sortKey="Zhang, Chao" sort="Zhang, Chao" uniqKey="Zhang C" first="Chao" last="Zhang">Chao Zhang</name></author><author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name></author><author><name sortKey="Li, Taisheng" sort="Li, Taisheng" uniqKey="Li T" first="Taisheng" last="Li">Taisheng Li</name></author><author><name sortKey="He, Yuxian" sort="He, Yuxian" uniqKey="He Y" first="Yuxian" last="He">Yuxian He</name></author></analytic><series><title level="j">Virology journal</title><idno type="eISSN">1743-422X</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Neutralizing (blood)</term><term>Antibodies, Viral (blood)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Follow-Up Studies</term><term>Humans</term><term>Membrane Glycoproteins (immunology)</term><term>Neutralization Tests</term><term>Protein Structure, Tertiary</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Spike Glycoprotein, Coronavirus</term><term>Time Factors</term><term>Viral Envelope Proteins (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Anticorps neutralisants (sang)</term><term>Facteurs temps</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires (immunologie)</term><term>Humains</term><term>Protéines de l'enveloppe virale (immunologie)</term><term>Structure tertiaire des protéines</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Test ELISA</term><term>Tests de neutralisation</term><term>Virus du SRAS (immunologie)</term><term>Études de suivi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Membrane Glycoproteins</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Glycoprotéines membranaires</term><term>Protéines de l'enveloppe virale</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Follow-Up Studies</term><term>Humans</term><term>Neutralization Tests</term><term>Protein Structure, Tertiary</term><term>Spike Glycoprotein, Coronavirus</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Facteurs temps</term><term>Glycoprotéine de spicule des coronavirus</term><term>Humains</term><term>Structure tertiaire des protéines</term><term>Test ELISA</term><term>Tests de neutralisation</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The spike (S) protein of SARS-CoV not only mediates receptor-binding but also induces neutralizing antibodies. We previously identified the receptor-binding domain (RBD) of S protein as a major target of neutralizing antibodies in animal models and thus proposed a RBD-based vaccine. However, the antigenicity and immunogenicity of RBD in humans need to be characterized.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><noCountry><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name><name sortKey="He, Yuxian" sort="He, Yuxian" uniqKey="He Y" first="Yuxian" last="He">Yuxian He</name><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><name sortKey="Li, Taisheng" sort="Li, Taisheng" uniqKey="Li T" first="Taisheng" last="Li">Taisheng Li</name><name sortKey="Liu, Lifeng" sort="Liu, Lifeng" uniqKey="Liu L" first="Lifeng" last="Liu">Lifeng Liu</name><name sortKey="Zhang, Chao" sort="Zhang, Chao" uniqKey="Zhang C" first="Chao" last="Zhang">Chao Zhang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Cao, Zhiliang" sort="Cao, Zhiliang" uniqKey="Cao Z" first="Zhiliang" last="Cao">Zhiliang Cao</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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